The Bene Tleilax had always believed in the advent of the super-being, the Kwisatz Haderach, who would ease humnanity into the next stage of evolution. In Paul of Dune, by Brian Herbert and Kevin J Anderson, the Tleilaxu created twelve clones of a near-perfect physical and super-intelligent male human beings, which they named Thallo.
They awakened the first clone of Thallo in Thalidei, and told him of his destiny to lead mankind. Thallo, having the ability to see the future through prescience, knew that he would fail, and that his future was hopeless.
The Fenrings and Death
When Count Hasimir Fenring, his wife Margot Fenring, and adopted daughter Marie Fenring, visited the Tleilax to learn about the concept of twisting personalities; Thallo took Marie as a type of friend. He confided in Marie his concerns about his future, and his intention to commit genocide and suicide. As Thallo prepared to flood the city of Thalidei and the laboratory with deadly nerve gas, Marie was left with no choice but to show her skills as an assassin. She immediately killed Thallo, and the Tleilaxu Kwisatz experiment was discontinued.