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Heretics of Dune, written by Frank Herbert, is the fifth novel in the original Dune series. 1,500 years have passed since Leto II's reign ended; humanity is set firmly on the Golden Path. By crushing the aspirations of humans for 3,500 years, Leto caused The Scattering, an explosion of humanity into the unknown universe upon his death.

Now, some of those who went out into the universe are coming back into the realms of the Old Imperium, bent on conquest. Only the Bene Gesserit perceive the Golden Path, and are faced with a choice: keep to their traditional role of hidden manipulators, quietly easing tensions and guiding human progress while struggling for their own survival; or embrace the Golden Path and push humanity onward into a new future where humans are free from the threat of extinction.